Just depends on tire size and how much weight do you really put in it.
I'm running 32 inch tires on my 88 Suburban, with a 2.5 lift. I do not plan to go any bigger than 33's ever. I don't extreme wheel it, rock crawl, or other "hard" use. I have done some killer upgrades to my axles, but nothing that overtly increased the overall strength. I'll be keeping the 10 bolts, they'll outlive the truck if not abused.
Now, the upgrades.............. which you may or may not want to copy.
1) 2010 Four piston Hummer H3 front brake calipers and rotors, running 14x1.5 late model lugs.
2) Complete 2004 Silverado rear disk brake axle, which is also wider than the stock axle eliminating rear spacers.
You will need bigger rims if you decide to go with the brake upgrades.