WARNING: This information is from 1995-2003 when I was backpacking like, once a month. I stick to this. However I know that camping equipment and techniques have evolved significantly so what I have to say may not be valid anymore. I hope others can weigh in on this to change/update what is said here. That said, here I go.
Yes. Taking care of your feet is a significant priority. If your feet got to crap, you are in trouble.
From my experience, I would always wear silk liners then thick socks. Of course my boots were broken in with this sock configuration.
Whenever I would get a hot spot, I'd stop and put duct tape on my foot. Removing duct tape from foot > big toe engulfing blister.
Rotate out your socks. Carry a fresh pair for each day. Keep your feet dry. Oh FYI, DO NOT dry your boots out next to the fire. Guess what kills waterproofing of your boots...
Try to bring a set of campsite shoes. I always use lightweight Chacos for this during the summer and I have these little insulated booties for winter. They look goofy as all get out but omg they are so warm and comfortable. By doing this, you give your boots extra time to dry out and to give your feet a rest.
Keep said shoes handy if you end up doing one hour lunch breaks. Great time for your foot gear to dry out from the morning sweat. Keeping your camp shoes on a carabiner on the back of your pack is great IF you have good weather. Otherwise put them in the top of your pack so they are right there when you stop.
Carry an ACE bandage with you and learn how to do a proper ankle wrap. Youtube should help you with this. Learn how to properly apply heal locks and figure eights. If you have ankle issues, this can really help keep you going. An improperly wrapped ankle can help, but a properly wrapped ankle can make you feel brand new.
If you don't have legit hiking boots, get those first.
For break in, make sure they are clean and just start wearing them. At work, as long as I'm not wearing a suit, no one notices when I'm wearing hiking boots. I'll wear my boots a week before I do any major hiking or if we have inclement weather here (why kill my nice leather shoes when my boots are Goretex?).
Lastly, trim your toe nails one week before you go. That way your toe nails aren't so long that they stab the toe of the boot, but your toes aren't tender from the recent trimming. I know, TMI, but crucial.
So yeah, that is all I know on the subject.