Hello everyone. I was just surfing this thread and thought that I'd chime in give my 2 cents.
A lot people tend to confuse stiffness and strength. They are related but not the same. For example, a soda can is very stiff for it's weight, but would you call it "strong"? On the other hand, a piece of rebar (let's say a 2 foot length of #3 bar) is heavy but can be flexed by your bare hands, would you consider it "weak"?
If you want torsional stiffness, a unibody has ANY body on frame beat by a mile and a half in a one mile race. I recall reading somewhere when the Ridgeline debut that Honda claimed it is 20 times stiffer in torsion than the best BOF compact pickup currently on the market and 2.5 times stiffer in bending. And I have no reason to doubt that claim. Unibodies are just naturally stiffer than BOF. But stiffness does not equal strength. And strength to me is robustness, or the ability to handle a wide range of loading scenarios, the ability to be pushed a little too hard beyond it's intended design, including overloading without yielding. That robustness actually comes from a BOF ability to flex and that thick frame absorbing a majority of the loading instead of passing it onto the sheet metal body as is the case in a unibody.
That same reasoning can be used in the boxed section vs c-channel frame. A boxed section frame is stiffer in torsion. That's basic mechanics of material. But is a boxed section frame stronger, more robust? The answer is probably not, if all things being equal. Yes, it's stiffer in torsion but about the same or even less in bending. The extra flex inherent in a c-channel frame is actually preferred in the heavy haul industry from a durability stand point because dynamic loading is not so much about the magnitude of the dynamic force but more about the magnitude of the dynamic displacement. Being able to flex without yielding is good that's why the RAM 4500 and 5500 uses a c-channel frame and riveted cross members instead welded cross members. The ability to easily upfit a c-channel is another plus, but boxed section frames can be upfit without much trouble too. Both types are frame are good for their intended purpose, but each has as many pros and cons as the other. Saying one is better than the other would be a lacking of discernment.
In terms of NVH, it really comes down to the tuning of the bushings and suspenion and the body construction than the design choice of the chassis.