I've thought about it a few times. Since moving to our new house, we've a 90 minute commute each way, but we bought the house primarily to have a space to work on the truck. Once we finish it off though, fully expect to drive it to Melbourne, find a quiet space to park within walking distance to work and camp down for the week. Have shower/toilet both onboard and at work so keeping clean isn't too much of a problem.
People at work look at me like I'm slightly crazy when I tell them my plans, but they think I'm a little that way anyway.
Anyway, I think the van should be fine, so long as you don't leave rubbish around and keep it clean/not smelly. Showering, toilet and laundry will likely be the biggest things, most people I know ignore a van parked except if something looks out of place. Blockout blinds on the windows, some kind of removable partition wall behind the drivers seats (so they look in, see a blank wall, think it a work van) will do a lot I think.