With the van fridge I usually turn it off 10-11 PM and restart 7-8 AM. In this case it's because of the humming noise when it cycles, not because of any battery concerns as I have two G27 house batteries in the van.
In the Cruiser I just have the starting battery. I could carry a jump starter I suppose but it's one more piece of gear in the way. The guy at Dometic customer service said the low battery indicator would shut the thing off before I drained the battery and that it would keep things cold for hours without running.
The stuff I'd tend to put in there would be eggs, butter, cheese, lunch meats, yogurt, and beer. I suspect none would spoil overnight but I'd rather not take the chance.
BTW, espressomon, if you were traveling solo, able to resupply, and didn't have the 50 would you find the CF25 sufficient for two-three days? They don't have the same open interior of a typical 25 qt cooler but it seems like it would be big enough for me. Even the 18 might do but the 25 weighs the same, doesn't have a much bigger footprint, and draws the same power for just $100 more than the 18 at American RV Co.