I take mine, (3 Cans on the rear bumper rack) from about 6,800ft down to about 125ft and back all the time with no problems, I even had them on the back when I drove to the top of Pikes Peak with no problems. You should open them slow at first, they will sound like opening a carbonated drink.

2003 Ford E-350SD 4x4
V10 / 4R100 / NV271
Front Axle - 1 Ton Spec Dana 60 / King Pin / Open Knuckle / High Steer
Rear Axle - 1 Ton Spec Dana 60 / Full Floating
Eaton E-Lockers Front And Rear / 4:10 Gears
ARB Differential Covers / Nodular Iron With Dipstick And Drain Plug
Leaf Spring Suspension Front And Rear
46 Gal Transfer-Flow Fuel Tank
ExtremeAire Magnum Air Compressor
Reunel Rear Bumper
On And On ...