With long Fullsize trucks you just have to slow down and use good tires. No half bald MT's. It's not bad at all with the Yukon or Detroit Lockers in the rear, but you have to drive responsibly in the wet/snow. Truetrac F, Detroit R is a perfect combo for fullisze trucks. Just avoid the Truetrac rear, it's disappointing.
If your F150 has a modular engine you can get by running higher RPM's and lower gears. Anything less than 4.10 is lame, even in Mustangs. I think 4.30 and 33" tires would be a good all around compromise. Not to much, not too little. If I regear I'm going to 4.56 for 33-35" tires on my truck. I allready have 4.10's, so I wouldn't even feel the difference with4.30.
'08 Ford F250 XL
Half of a '94 Jeep YJ
'02 Honda CRF450r, '04 Ford Mach1